LDL Isolation and Copper-Catalysed Oxidation
نویسندگان
چکیده
منابع مشابه
Tuneable asymmetric copper-catalysed allylic amination and oxidation reactions.
Asymmetric allylic amination or oxidation can be achieved by reaction of an alkene with a peroxycarbamate catalysed by a chiral copper bis-oxazoline complex, and the reaction can be tuned to give either the amination or oxidation product by reagent choice.
متن کاملFragmentation and dimerization of copper-loaded prion protein by copper-catalysed oxidation.
Prion protein consists of an N-terminal domain containing a series of octapeptide repeats with the consensus sequence PHGGGWGQ and a C-terminal domain composed of three alpha-helices and two short beta-strands. Several studies have shown that the N-terminal domain binds five Cu2+ ions. In the present study, we have investigated copper-catalysed oxidation of a recombinant mouse prion protein, Pr...
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Extracorporeal reduction of plasma low density lipoproteins (LDLs) by LDL apheresis was shown to attenuate the proatherogenic influences of LDL, such as impairment of vasodilation and increased monocyte adhesion to the endothelium. In 16 patients with familial hypercholesterolemia, we analyzed whether LDL apheresis by the heparin precipitation procedure affected the oxidative resistance of LDL....
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In peripheral blood, native low-density lipoprotein (LDL) is a major carrier of acetylhydrolase, the enzyme that hydrolyzes the sn-2 acetate of PAF-acether, converting it to lyso PAF-acether. By controlling the level of PAF-acether, the acetylhydrolase may regulate the biologic effects of this potent inflammatory and thrombotic mediator. The biologic oxidation of LDL appears to underlie its ath...
متن کاملLDL oxidation and extent of coronary atherosclerosis.
Accumulated evidence indicates that oxidative modification of LDL plays an important role in the atherogenic process. Therefore, we investigated the relation between coronary atherosclerosis and susceptibility of LDL to oxidation in a case-control study in men between 45 and 80 years of age. Case subjects and hospital control subjects were selected from subjects undergoing a first coronary angi...
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ژورنال
عنوان ژورنال: Pharmaceutica Analytica Acta
سال: 2013
ISSN: 2153-2435
DOI: 10.4172/2153-2435.1000247